关于beplay体育博士后工作站

beplay体育于2021年12月获批设立博士后工作站，与beplay体育药学院联合招收及培养博士后，为有志从事创新药物研发的博士毕业生提供广阔的发展平台。beplay体育提供有竞争力的薪酬、年假以及全面社保等福利，并致力于创造一个充满活力、包容和多元化的工作环境，使个人拥有快速成长的发展空间和一份有趣、有价值、有使命感的事业！

2022年博士后招募计划：

职位1：博士后研究员，疾病生物学(分枝杆菌微生物组)

课题方向：

可选方向一：用系统微生物学组学等方法分析抗分枝杆菌化合物的作用机理，以及用分子遗传学手段验证。

可选方向二：建立基于细菌靶点（复制，转录，翻译和生物合成酶等）的小分子抑制剂筛选方法，用分子生化或全微生物细胞系统进行药物筛选及体外实验验证。

专业要求：

微生物学、分子化学生物学、生物化学、系统生物学、生物工程学、免疫学等相关生物学科博士毕业生，有结核病或分枝杆菌模型研究经验优先

职位2：博士后研究员，疾病生物学(抗病毒组)

课题方向：

通过小分子筛选及分子设计等策略，发展慢性乙型肝炎功能性治愈药物

专业要求：

微生物学、生物工程或基础医学等相关专业博士毕业，有病毒学研究背景者优先

职位3：博士后研究员，药物化学

课题方向：

冠状病毒小分子药物研发项目在靶点验证、先导阶段和优化阶段中的药物化学研究

专业要求：

药物化学、有机化学等相关学科博士毕业生

职位4：博士后研究员，高通量筛选平台

课题方向：

建立可同时测量多基因表达的定量分析方法，并将其应用于新药研发早期的靶点发现，靶点验证，和药物作用机理研究。涉及领域包括RNA分析，二代测序， 高通量筛选。

专业要求：

细胞生物学，分子生物学，遗传学，基因组学和生物化学等相关学科博士毕业生

职位5：博士后研究员，蛋白质科学

课题方向：

运用生物物理，生物化学，注重于结构生物学的实验技术，对于具有生物学功能的新的蛋白靶点，例如与其他疾病生物学和信息生物学的发现和专注的药物靶点，通过结构功能的解析，辅助药物靶点的筛选，验证以及药物分子的开发。

专业要求：

生物物理，生物化学，结构生物学相关专业博士毕业生，具有晶体学，冷冻电镜，核磁共振，以及其他生物物理和生物化学研究背景优先。

招聘基本要求：

1. 在国内外获得博士学位的应届博士毕业生（申请时须已满足博士学位论文答辩的基本要求），年龄在35岁以下

2. 能全职在本站从事博士后研发工作

3. 博士所从事的研究方向和专业符合本站博士后岗位的要求

为什么选择beplay体育博士后工作站?

1. 您可以探索和了解从早期药物发现至临床前IND研究的全流程并参与其中

2. beplay体育与beplay体育药学院双导师制，让您可以与顶尖的国内外工业界及学术界专家一起工作

3. beplay体育良好的学术氛围及文化、丰富的培训及学习机会帮助您快速成长

4. beplay体育国际一流的研发实验平台及全球研发资源网络为您提供广阔视野

5. beplay体育与beplay体育药学院实力联动、联合培养模式为您创造更多机会

您可以享受到：

1. 有竞争力的薪酬及全面社保

2. 按博士后管理政策享受出站落户、在站子女入学协助等

3. 带薪年休假及中心其他福利假

4. 补充医疗保险（包括子女）及年度健康体检

5. 博士后出站后可继续在beplay体育工作

申请方式：

请发送个人简历（包含以往研究介绍、论文等）至 career@joncarolino.com， 邮件主题中请注明“应聘博士后”及应聘部门。

主要职责

• Lead the Disease Biology group composed of teams in multiple disease areas, including but limiting to TB, Malaria and Anti-viral, to develop innovative therapeutic drugs.

• Oversee and manage the overall biology supports to ensure the progress and delivery of beplay体育’s project portfolio.

• Manage the initiation of exploratory projects from biology point of view to form a comprehensive R&D pipeline.

• Work closely with CEO and CSO to establish biology strategy which fits to the overall strategy for beplay体育’s long term development.

• AS the biology lead, actively and frequently communicate with and manage individual disease area heads and consultants.

• As the biology representative and the member of core science leadership team, closely communicated with BMGF, TBDA, MMV and CARE etc.

• Strengthen and develop domestic and international networks in related disease areas for expertise and collaborations.

任职要求

• Ph.D. in biology/general anti-infectives.

• 10+ years’ broad biology experience in pharmaceutical industry (preferred) and/or academic research in anti-infectious small molecule drug development and biological product development (plus);

• Capability to lead, manage and mentor a multidiscipline biology group (20-30 scientists) to meet overall beplay体育’s R&D portfolio goal.

• Insight and vision on the R&D direction and strategies from biology point of view, particularly in global disease areas including TB, Malaria or anti-viral.

• Excellent verbal and written communication/presentation skills in both English and Chinese; be able to routinely talk, present and write to internal and external colleagues/consultants/collaborators/governors.

• Highly self-motivated team leader and a team player in the matrix scientific work environment.

工作地

北京市海淀区永泰庄北路1号

关于beplay体育

全球健康药物研发中心（Global Health Drug Discovery Institute，简称“beplay体育”）是由beplay体育和beplay体育发起，北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题，致力发展杰出的生物医药研究与开发能力，建设新药研发和转化的创新平台，为解决发展中国家面临的突出疾病挑战做出贡献。

beplay体育

申请者请发送个人简历以及代表性论文清单至 career@joncarolino.com. 

* 该职位享有“人才招募推荐计划”。

主要职责

• Create, develop and validate quantitative mammalian cellular assays to address the project team’s mechanistic and functional needs.

• Establish robust screening assays to support medicinal chemistry lead optimization programs.

• Design and manage in vivo pre-clinical pharmacokinetics, pharmacodynamics, and toxicity studies.

• Design and manage physiological experiments in translational disease models to test efficacy and mechanism of action of novel clinical candidates.

• Establish PK/PD relationships, demonstrating proof-of-concept, enabling candidate selection and delivering data for clinical dose predictions in preclinical in vivo experiments.

• Establish pharmacology strategy in alignment with company pipeline objectives.

• Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way

• Bring forward innovative ideas, novel translational animal models and advanced technologies to support team goals.

• Identify, evaluate, and manage vendors for outsourced services and studies.

• Prepare reports for internal and external purposes including regulatory submissions.

• Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies.

• Develop and continually advance one’s knowledge base on the molecular pathways being targeted by discovery and development research programs.

• Identify opportunities and develop ideas to enhance and accelerate business processes.

• Cultivates cross-functional relationships with project teams, translational medicine, biomarker teams, and disease-specific working groups to deliver novel targets, biomarkers and drug candidates.

• Responsible for achieving pipeline goals by managing resource allocation and oversight of progress.

• Present scientific accomplishments internally and externally to the scientific community and discussed with key opinion leaders.

• Responsible for career development of team of diverse scientists, contribute to talent strategy and provide mentorship to group.

任职要求

• PhD in Biology, physiology, pathology or pharmacology with relevant postdoctoral experience and at least 5 years biotech/pharma working experiences.

择优要求

• Extensive experience in creating, developing, and running cellular assays; engineering cell lines to express or knock-down genes of interest, and interrogating cellular signal transduction pathways.

• Experience with flow cytometry and general molecular biological techniques including q-PCR, ELISA, MSD and Western Blot etc.

• Strong background in designing in vivo animal studies.

• Strong knowledge of cell cycle arrest, apoptosis, and senescence

• Experience in oncology and knowledge p53 signaling pathway is a plus

• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.

• Committed to staying current with the latest scientific breakthroughs in the targeted oncology field from target identification through human clinical trials.

工作地

北京市海淀区永泰庄北路1号

关于beplay体育

全球健康药物研发中心（Global Health Drug Discovery Institute，简称“beplay体育”）是由beplay体育和beplay体育发起，北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题，致力发展杰出的生物医药研究与开发能力，建设新药研发和转化的创新平台，为解决发展中国家面临的突出疾病挑战做出贡献。

beplay体育

申请者请发送个人简历以及代表性论文清单至 career@joncarolino.com. 

* 该职位享有“人才招募推荐计划”。

主要职责

• 研究小分子抗生素化合物的作用机理。

• 用系统生物学和各类组学的方法确立药物靶点并进行验证。

• 开发可用于药物筛选的分子与生化反应体系，特别是细菌基因的转录翻译过程, 和细菌的细胞壁合成与能量代谢途径。

• 开发实验动物细菌感染模型用于靶点和小分子药物的研究。

任职要求

• 已取得分子生物化学，微生物遗传，医学微生物，动物兽医或相关生物科学硕士或博士学位，具有0-6年相关经历。

• 具有研究细菌传染病和实验动物模型的科研经历，和有优良的数据分析能力的申请人会被优先考虑。

• 具备良好的团队合作精神，优秀的协作能力和英文沟通能力。

• 应聘者必须具备严谨的科研素养，并能严格对实验记录和电子文档进行归档整理。

工作地

北京市海淀区永泰庄北路1号

关于beplay体育

全球健康药物研发中心（Global Health Drug Discovery Institute，简称“beplay体育”）是由beplay体育和beplay体育发起，北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题，致力发展杰出的生物医药研究与开发能力，建设新药研发和转化的创新平台，为解决发展中国家面临的突出疾病挑战做出贡献。

beplay体育

申请者请发送个人简历以及代表性论文清单至 career@joncarolino.com. 

* 该职位享有“人才招募推荐计划”。

主要职责

• Responsible for genetic manipulation with Mycobacterium and/or other bacterial pathogens, developing phenotypic assays and HTS for antibacterial.

• To identify antibacterial drug target, analyze the mode-of-action of small molecule, and bacterial strain typing and genome sequence analysis.

• Develop knowledge to strengthen the medical and pharmaceutical aspects of the projects.

• Facilitate both internal and external collaborations, and provide scientific expertise across functions/teams.

任职要求

• PhD degree in microbiology or the related biological sciences with proven record of accomplishment. Experience in Mycobacterium model organisms (M. tuberculosis, M. smegmatis, M. bovis BCG, etc.) is highly appreciated.Industrial or CRO experience in whole bacterial cell screen against small molecule library is preferred. Animal model and/or pharmacology experience would be a plus.

• Have at least five years of experience and in-depth understanding of general microbiology, bacterial genetics, and microbial biochemistry.

• Highly self-motivated, and be willing to work diligently in a collaborative and dynamic team environment. Strong oral and written capability in English.

• Result driven, multi-task, communicate clearly and present in a professional manner.

• Scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.

工作地

北京市海淀区永泰庄北路1号

关于beplay体育

全球健康药物研发中心（Global Health Drug Discovery Institute，简称“beplay体育”）是由beplay体育和beplay体育发起，北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题，致力发展杰出的生物医药研究与开发能力，建设新药研发和转化的创新平台，为解决发展中国家面临的突出疾病挑战做出贡献。

beplay体育

申请者请发送个人简历以及代表性论文清单至 career@joncarolino.com. 

* 该职位享有“人才招募推荐计划”。

主要职责

As a senior biologist, you will play key roles in target evaluation/validation, hit identification, hit validation and MOA studies in drug discovery process. Your responsibilities include, but not limit to the following：

• Apply biology and cellular pharmacology knowledge and skills to design and execute biochemical and in vitro cellular experiments involving the evaluation of small molecule modulators.

• Develop and validate a variety of cellular assays to understand the target of interest and characterize small molecule inhibitors/activators.

• Establish robust screening assays to support medicinal chemistry lead optimization programs and contribute to DC (development candidate) identification for ongoing drug discovery projects.

• Design and manage in vivo pre-clinical pharmacokinetics, pharmacodynamics, and toxicity studies.

• Coach and develop research associate/junior scientist in experimental design, data management and analysis.

• Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way.

• Bring forward innovative ideas, novel translational animal models and advanced technologies to support team goals.

• Maintain and routinely employ in-depth knowledge of project-related scientific literature

任职要求

• PhD in Biology, physiology, pathology or pharmacology with relevant postdoctoral experience and at least 3 years biotech/pharma working experiences.

• Extensive experience in creating, developing, and running cellular assays; engineering cell lines to express or knock-down genes of interest, and interrogating cellular signal transduction pathways.

• Experience with flow cytometry and general molecular biological techniques including q-PCR, ELISA, MSD and Western Blot etc.

• Strong background in designing in vivo animal studies.

• Strong knowledge of cell cycle arrest, apoptosis, and senescence

• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.

• Committed to staying current with the latest scientific breakthroughs in the targeted oncology field from target identification through human clinical trials.

工作地

北京市海淀区永泰庄北路1号

关于beplay体育

全球健康药物研发中心（Global Health Drug Discovery Institute，简称“beplay体育”）是由beplay体育和beplay体育发起，北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题，致力发展杰出的生物医药研究与开发能力，建设新药研发和转化的创新平台，为解决发展中国家面临的突出疾病挑战做出贡献。

beplay体育

申请者请发送个人简历以及代表性论文清单至 career@joncarolino.com. 

* 该职位享有“人才招募推荐计划”。

主要职责

• 开发实验方法，执行高通量筛选和其他生物实验

• 分析实验数据，同化学家一起对化合物进行潜力评估

• 靶点识别，验证和机制研究

• 与内外部其他部门/团队密切合作并提供专业意见

任职要求

• 微生物学，免疫学，细胞生物学或其他相关专业， 博士学历，0-5年工作经验

• 具有宿主-细菌相互作用或细胞免疫学经验者优先，具有实验方法开发和高通量筛选经验者优先

• 对科研工作有热情及兴趣，富有团队合作精神, 适应在动态的，多部门合作的环境中工作，具有良好的英语沟通交流能力。

• 工作严谨诚信，有良好的实验记录习惯

工作地

北京市海淀区永泰庄北路1号

关于beplay体育

全球健康药物研发中心（Global Health Drug Discovery Institute，简称“beplay体育”）是由beplay体育和beplay体育发起，北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题，致力发展杰出的生物医药研究与开发能力，建设新药研发和转化的创新平台，为解决发展中国家面临的突出疾病挑战做出贡献。

beplay体育

申请者请发送个人简历以及代表性论文清单至 career@joncarolino.com. 

* 该职位享有“人才招募推荐计划”。

主要职责

• Work closely with medicinal chemistry, structural biology, and DMPK teams and help select and advance screening hits.

• Characterize and profile small molecules with biological activities.

• Initiate, facilitate, and organize domestic and international collaborations with academic and industrial partners.

• Take a leadership role for data analysis and nominate novel strategies.

• Generate written reports and oral presentations for monthly and quarterly meetings and annual reports.

• Present findings at international meetings and publish in scientific journals.

任职要求

• Have a Ph.D. in microbiology, molecular/cell biology, parasitology, vector biology, chemical biology, or any related area with a minimum of 0-4 years of post-graduate research experience for the post-doc position and 2 to 7 years experience for the Scientist or Investigator position. MDs who are interested in microbiology, molecular biology, drug discovery or DVMs who are interested in tropical zoonotic/livestock diseases or comparative medicine are also encouraged to apply.

• Have a broad understanding and curiosity of cutting-edge technologies and challenges in anti-microbial drug discovery.

• Have basic oral and written English communication skills.

• Be capable of working in an interactive and multidisciplinary team environment while conducting self-directed research within broader goals set by the group.

• Possess excellent organizational skills and the ability to interact effectively with an international network of laboratories and disease experts.

• Be meticulous in maintaining lab notebooks and data filing.

• Those with in-depth knowledge in genomics, genome editing, chemical biology, systems biology, biomarker discovery, or in vivo animal model studies will be preferred.

• Hands-on experiences in vitro cell culture, microscopy, flow cytometry, and animal studies are ideal but not required.

工作地

北京市海淀区永泰庄北路1号

关于beplay体育

全球健康药物研发中心（Global Health Drug Discovery Institute，简称“beplay体育”）是由beplay体育和beplay体育发起，北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题，致力发展杰出的生物医药研究与开发能力，建设新药研发和转化的创新平台，为解决发展中国家面临的突出疾病挑战做出贡献。

beplay体育

申请者请发送个人简历以及代表性论文清单至 career@joncarolino.com. 

* 该职位享有“人才招募推荐计划”。

主要职责

• Assist other scientists in biochemistry and cell biology assay developments

• Be responsible for routine experiments and maintenance as assigned by the supervisor, strictly abide by the standard operating procedures.

• Be responsible for data collection, analysis, and keeping a high-quality experimental record

• Present routine works at internal meetings

任职要求

• MS or BS degree with 0-6 years of relevant working experience in molecular biology/cell biology/biochemistry is required

• Solid skills in molecular/biochemical/cell biology such as molecular cloning, PCR, RT-PCR, protein extraction, and western blot is desirable

• Experience in cell-based screening assays and luciferase reporter assays and small molecule drug discovery is a plus but not required

• Candidates must be highly self-motivated and have good communication skills to work in a collaborative and dynamic team environment.

• Scientific integrity is a must; candidate should be professional in maintaining lab notebooks and electronic files.

工作地

北京市海淀区永泰庄北路1号

关于beplay体育

全球健康药物研发中心（Global Health Drug Discovery Institute，简称“beplay体育”）是由beplay体育和beplay体育发起，北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题，致力发展杰出的生物医药研究与开发能力，建设新药研发和转化的创新平台，为解决发展中国家面临的突出疾病挑战做出贡献。

beplay体育

申请者请发送个人简历以及代表性论文清单至 career@joncarolino.com. 

* 该职位享有“人才招募推荐计划”。

主要职责

• Perform routine in vitro potency assays and maintenance of cell lines.

• Assist other scientists in assay development and high throughput screening.

• Data analysis and keeping lab databook

任职要求

• Bachelor or Master's degree with 0-6 years working experience in biology or other related fields.

• Experience in basic molecular/cell biology procedures, such as cell culture, molecular cloning, DNA sequence analysis, protein expression, and purification.

• Self-motivated and have good communication skills in English to work in a collaborative and dynamic team environment.

• Experience in animal studies (in mouse or rat) is a plus.

• Expertise in “R” is also a plus.

• Scientific integrity is a must; candidates should maintain lab notebooks and electronic files.

工作地

北京市海淀区永泰庄北路1号

关于beplay体育

全球健康药物研发中心（Global Health Drug Discovery Institute，简称“beplay体育”）是由beplay体育和beplay体育发起，北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题，致力发展杰出的生物医药研究与开发能力，建设新药研发和转化的创新平台，为解决发展中国家面临的突出疾病挑战做出贡献。

beplay体育

申请者请发送个人简历以及代表性论文清单至 career@joncarolino.com. 

* 该职位享有“人才招募推荐计划”。

主要职责

• 领导一个或多个小分子药物研发项目在靶点验证、先导阶段和优化阶段中的药物化学工作。

• 与跨学科的核心研发团队成员协作，设计并实施研发项目发展战略，以推进项目成功取得高质量临床前候选化合物。

• 独立从事药物分子设计与构效关系研究，以完成设定的项目目标；设计合成路线，并引领研究中心和外部合作伙伴公司的化学团队合成与鉴定候选药物。

• 与计算化学团队紧密合作，设计基于结构的靶标分子。

• 积极沟通项目的发展战略和关键问题，以做出合适的资源决策。

• 管理和监督团队工作，并为团队成员提供科学指导和技术培训。

• 与研究中心内部和外部的研究团队建立高效的沟通机制。

任职要求

• 已取得化学或其他相关领域的博士学位。

• 应聘者须具备五年以上在药物化学领域的工作经历；具有在制药/生物科技行业小分子药物研发的实践经验及临床前研发经验的应聘者将获得优先考虑。

• 在小分子候选药物的临床前研发方面有着突出的个人与团队贡献，包括发表过高水平的学术论文，口头报告与专利申请等。

• 具有优秀的有机化学背景和专业知识，以及包括新合成路线设计能力等高水平的合成技能。

• 具有项目领导经验以及在小分子药物研发的各阶段制定战略和重要决策的能力。

• 优秀的解决问题能力及人际沟通能力，能在团队环境中与机构其他的研发或管理人员高效协同工作。

• 具有良好的领导或者与CRO的化学团队合作经验更佳。

工作地

北京市海淀区永泰庄北路1号

关于beplay体育

全球健康药物研发中心（Global Health Drug Discovery Institute，简称“beplay体育”）是由beplay体育和beplay体育发起，北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题，致力发展杰出的生物医药研究与开发能力，建设新药研发和转化的创新平台，为解决发展中国家面临的突出疾病挑战做出贡献。

beplay体育

申请者请发送个人简历以及代表性论文清单至 career@joncarolino.com. 

* 该职位享有“人才招募推荐计划”。

主要职责

• 负责在实验室中领导并执行研究项目的化学发展战略。

• 在靶点验证阶段、先导阶段和优化阶段的研究项目中独立设计和开展候选药物的高效合成、纯化和表征。

• 开发并应用创新的合成手段及药物化学专业技能，构建构效关系。

• 在团队资深成员的监督指导下设计生物活性分子，并开展SAR研究以达成项目目标。

• 与计算化学团队紧密合作，开发基于结构的靶点分子。

• 为团队成员提供科学指导和技术培训。

• 监督并管理外部化学团队以高质量执行研究项目中的化学计划。

• 扩大机构对外的学术影响力，包括撰写科学出版物和演示文稿。

任职要求

• 已取得化学或相关领域的博士学位，以及至少1年的药物研发行业经验。

• 应聘者必须具有优秀的有机化学背景和专业知识（方法、催化、全合成等），以及解决复杂问题的丰富经验。

• 优秀的解决问题能力及人际沟通能力，能在团队环境中与机构其他的研发或管理人员高效协同工作。

• 具有良好的领导或与CRO的化学团队合作经验更佳。

工作地

北京市海淀区永泰庄北路1号

关于beplay体育

全球健康药物研发中心（Global Health Drug Discovery Institute，简称“beplay体育”）是由beplay体育和beplay体育发起，北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题，致力发展杰出的生物医药研究与开发能力，建设新药研发和转化的创新平台，为解决发展中国家面临的突出疾病挑战做出贡献。

beplay体育

申请者请发送个人简历以及代表性论文清单至 career@joncarolino.com. 

* 该职位享有“人才招募推荐计划”。

主要职责

• Apply his/her expertise and experience in molecular biology, protein chemistry and structure biology to provide high-quality proteins to other drug-discovery functions, including disease biology, HTS and Structure Biology for assay development, biochemical and biophysical characterization.

• Be proficient to use bioinformatic genetic data analysis, protein structure-function studies to design protein constructs for optimized protein expression in various expression systems, preferably proficient in using insect cells, mammalian cell expression systems.

• Be result-oriented, be able to independently design and execute the experiments; maintain accurate laboratory records on research data and operational details.

• As a biochemist, capable of integration of various molecular biology, biochemical, biophysical characterization tools for drug target characterization.

• Be a good team-player, willing to collaborate, actively communicate and eagerly learn new technologies.

任职要求

Minimal Requirement:

• A Ph.D degree or a MS degree with minimum of 3-5-year post-graduate working experience in the fields of Biochemistry and Biophysics, Structural Biology, Molecular Biology or any related fields.

Preferred to have:

• Experiences with structure determination techniques, including x-ray crystallography, cyro-EM or NMR is preferred.

• Extensive hands-on experiences in molecular biology techniques, recombinant protein production in various expression systems.

• An in-depth knowledge on protein biochemistry and biophysics is a must. Hands-on experiences in biophysical characterization techniques, including SPR, MST, DLS, DSP is a plus.

• Experience with molecular modeling, protein structure determination software, such as Phenix, COOT, CCP4, RELION, ability to use common structural visualization tools, including Pymol, for sharing structural information and structure analysis, is a plus.

工作地

北京市海淀区永泰庄北路1号

关于beplay体育

全球健康药物研发中心（Global Health Drug Discovery Institute，简称“beplay体育”）是由beplay体育和beplay体育发起，北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题，致力发展杰出的生物医药研究与开发能力，建设新药研发和转化的创新平台，为解决发展中国家面临的突出疾病挑战做出贡献。

beplay体育

申请者请发送个人简历以及代表性论文清单至 career@joncarolino.com. 

* 该职位享有“人才招募推荐计划”。

主要职责

• Apply expertise in protein expression/production, biochemistry/biophysical characterization, protein structure-function elucidation to aid the drug-discovery process at beplay体育.

• Work closely with Structure Biology Team members for integrated efforts for high quality and high efficiency protein production and protein characterization, structure determination research efforts, to provide key insights protein-functions analysis.

任职要求

• A MS degree with minimum of 3-5-year post-graduate working experience in the fields of Biochemistry and Biophysics, Structural Biology, Molecular Biology or any related fields.

• Have extensive hands-on experiences in molecular biology techniques, recombinant protein production in various expression systems.

• Proficient in various chromatography protein purification methods and protein characterization techniques. Hands on experiences with CD, DLS, MST and SPR protein analytic methods is a plus.

• In-depth knowledge on protein biochemistry and biophysics is preferred.

• Familiarity with structure determination techniques, including x-ray crystallography, cyro-EM or NMR is a plus.

• Be result-oriented, be able to independently design and execute the plans for protein construct design, expression and characterization.

• A good team-player, willing to collaborate, actively communicate, eagerly learn new technologies and share knowledge.

工作地

北京市海淀区永泰庄北路1号

关于beplay体育

全球健康药物研发中心（Global Health Drug Discovery Institute，简称“beplay体育”）是由beplay体育和beplay体育发起，北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题，致力发展杰出的生物医药研究与开发能力，建设新药研发和转化的创新平台，为解决发展中国家面临的突出疾病挑战做出贡献。

beplay体育

申请者请发送个人简历以及代表性论文清单至 career@joncarolino.com. 

* 该职位享有“人才招募推荐计划”。

About the Role

The successful candidate will primarily support the assay development and screening capabilities of the HTS Platform, using their scientific and technical skills to develop assays and carry out screening campaigns for internal projects and external collaborations. Additional support of other areas including cell culture and molecular biology is expected, when required.

Key Responsibilities

• Design and develop fit for purpose assays in close collaboration with Disease Biology colleagues.

• Support all aspects of assay development and screening including optimization and validation of assays to be executable on automation systems.

• Carry out and troubleshoot a variety of binding and competition assays, using techniques such as reporter cell line, FP, AlphaLISA/AlphaScreen, FRET/HTRF based assays and ELISA.

• Use liquid handling automation to support high throughput screening.

• Contribute to and support process improvements.

• Support data management by analyzing data and recording within laboratory notebooks.

• Prepare reports and recommendations to be shared with project teams and collaborators.

• Assist other areas of related functions, including cell culture and molecular biology, when required.

• Abide by Laboratory SOPs and work within EHS, Ethical and Quality standards.

Minimum Requirements

• PhD/MS in biological sciences (or equivalent).

• Experience in high throughput strategies from assay design to screening execution.

• Ability of follow and write standard operating procedures.

• Outstanding organizational and time management skills.

Preferred Qualifications

• PhD with a minimum of 3 years (or MS with 8+ years) of working experience in biochemical and/or cellular assay development and screening.

• Track record of contributing to successful outcomes on projects in academia and/or the Biotech/Pharma industry.

• Skilled in the use of high throughput screening strategies, assay cascade design, assay development, screening campaign, and data analysis.

• Detailed knowledge and understanding of technical principles, literature, and methods.

• Experience of applying data analytic theories such as multi-parameter curve fitting and EC / IC50 is required.

• Must possess and demonstrate strong written and verbal communication skills.

• Must be highly self-motivated and can work effectively in a collaborative team environment.

工作地

北京市海淀区永泰庄北路1号

关于beplay体育

全球健康药物研发中心（Global Health Drug Discovery Institute，简称“beplay体育”）是由beplay体育和beplay体育发起，北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题，致力发展杰出的生物医药研究与开发能力，建设新药研发和转化的创新平台，为解决发展中国家面临的突出疾病挑战做出贡献。

beplay体育

申请者请发送个人简历以及代表性论文清单至 career@joncarolino.com. 

* 该职位享有“人才招募推荐计划”。

About the Role

The successful candidate will primarily support the assay development and screening capabilities of the HTS Platform, using their scientific and technical skills to develop/optimize assays and carry out screening campaigns for internal projects, collaborations, and services to external customers. Additional support of other areas including cell culture and molecular biology is expected.

Key Responsibilities

• Design and develop fit for purpose assays in close collaboration with disease biology colleagues.

• Support all aspects of assay development and screening activities including assay optimization, validation, and execution on automation systems.

• Test and troubleshoot a variety of assay types, e.g. binding and competition assays, may use techniques such as reporter cell line, FP, AlphaLISA/AlphaScreen, FRET/HTRF based assays and ELISA.

• Use liquid handling automation to support high throughput screening.

• Contribute to laboratory process improvements.

• Support data management by analyzing data and recording within laboratory notebooks.

• Prepare reports and share with/present to project teams and collaborators.

• Assist related functions, e.g. cell culture, molecular biology, when required.

• Abide by Laboratory SOPs and work within EHS, Ethical and Quality standards.

Minimum Requirements

• MS in biological sciences (or equivalent) with 3 years of post-school laboratory working experience.

• Ability of follow instructions and create standard operating procedures.

• Good organizational and time management skills.

Preferred Qualifications

• MS with 5+ years or PhD with 2+ years of working experience in academic laboratories, CROs, or biotech/pharmaceutical industry.

• Track record of contributing to successful outcomes on projects

• Experiences in developing assays and/or carrying out screening campaigns for drug discovery are highly desired.

• Comprehensive knowledge, understanding, and experience of modern liquid handling technologies is a big plus.

• Experience of carrying out data analysis such as multi-parameter curve fitting, EC50/IC50 determination, or using excel macro to handle large dataset is advantageous.

• Must possess and demonstrate strong written and verbal communication skills.

• Must be highly self-motivated and can work effectively in a collaborative team environment.

工作地

北京市海淀区永泰庄北路1号

关于beplay体育

全球健康药物研发中心（Global Health Drug Discovery Institute，简称“beplay体育”）是由beplay体育和beplay体育发起，北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题，致力发展杰出的生物医药研究与开发能力，建设新药研发和转化的创新平台，为解决发展中国家面临的突出疾病挑战做出贡献。

beplay体育

申请者请发送个人简历以及代表性论文清单至 career@joncarolino.com. 

* 该职位享有“人才招募推荐计划”。

beplay体育于2021年12月获批设立博士后工作站，与beplay体育药学院联合招收及培养博士后，为有志从事创新药物研发的博士毕业生提供广阔的发展平台。beplay体育提供有竞争力的薪酬、年假以及全面社保等福利，并致力于创造一个充满活力、包容和多元化的工作环境，使个人拥有快速成长的发展空间和一份有趣、有价值、有使命感的事业！

课题方向：

从事新型抗感染策略及新型抗感染药物开发等方面相关的研究。建立基于药物作用靶点的化合物筛选方法；通过高通量筛选技术寻找能与靶点作用的小分子化合物；并进行药物作用机理研究，用以协助推动基础科研到转化应用的工作。

应聘条件：

1.    具有药物化学、药理学、分子生物学、细胞生物学及结构生物学等相关专业博士学位，获得博士学位3年以内，35岁以下；具有抗感染药物研究、酶学、化合物筛选等相关研究经验者优先考虑

2.    近3年以第一作者身份在国际知名学术期刊发表过研究论文

3.    热爱科研工作，刻苦好学，学风端正，责任心强，具备团队合作精神

4.    能够独立开展科研工作，具有较强的动手能力

5.    具备较好的英语沟通、阅读和写作能力。

为什么选择beplay体育博士后工作站?

1.    您可以探索和了解从早期药物发现至临床前IND研究的全流程并参与其中

2.    在beplay体育您可以深入了解多个抗感染领域新药研发的现状和策略

3.    beplay体育与beplay体育药学院双导师制，让您可以与顶尖的国内外工业界及学术界专家一起工作

4.    beplay体育良好的学术氛围及文化、丰富的培训及学习机会帮助您快速成长

5.    beplay体育国际一流的研发实验平台及全球研发资源网络为您提供广阔视野

6.    beplay体育与beplay体育药学院实力联动、联合培养模式为您创造更多机会

您可以享受到：

1.    有竞争力的薪酬及全面社保

2.    按博士后管理政策享受出站落户、在站子女入学协助等

3.    带薪年休假及中心其他福利假

4.    补充医疗保险（包括子女）及年度健康体检

5.    博士后出站后可继续在beplay体育工作

申请方式：

请发送个人简历（包含以往研究介绍、论文等）至 career@joncarolino.com， 邮件主题中请注明“应聘博士后”。

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